Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Published in:
Key Scientific Issues in Research for Quality Control of Chinese Medicines Read chapter Read first chapter

2024 | OriginalPaper | Chapter

5. Advance and Challenge of Component-Effect Relationship in the Discovery of Active Components from Chinese Medicines

Authors : Wen Cao, Shaoping Li, Jing Zhao

Published in: Quality Control of Chinese Medicines

Publisher: Springer Nature Singapore

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Active ingredients discovery has always been a hot topic for the research of Chinese medicines (CMs). The component-effect relationship is one of the widely used strategies for finding herbal active ingredients. This article systematically reviewed component-effect relationship analysis in the application of active components discovery in CMs, including sampling and sample preparation, chemical fingerprint establishment, pharmacological effect evaluation, and component-effect relationship analysis. The challenges to this method, such as the effects of dose–response relationship, data normalization, and the relationship analysis methods, were also discussed, which is helpful to well understand the method and improve the research quality.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now
previous chapter Bio-Specific Extraction/Receptor Fishing for Screening of Active Components in Chinese Medicines
next chapter Network Pharmacology to Clarify the Effective Substances and Their Action Mechanisms of Traditional Chinese Medicines
Literature
1.
J. Zhao, S.C. Ma, S.P. Li, Advanced strategies for quality control of Chinese medicines. J. Pharm. Biomed. Anal. 147, 473–478 (2018)PubMedCrossRef
2.
D.Q. Li, J. Zhao, D. Wu, S.P. Li, Discovery of active components in herbs using chromatographic separation coupled with online bioassay. J. Chromatogr. B 1021, 81–90 (2016)CrossRef
3.
S.P. Li, J. Zhao, B. Yang, Strategies for quality control of Chinese medicines. J. Pharm. Biomed. Anal. 55(4), 802–809 (2011)PubMedCrossRef
4.
C.S. Zhu, Z.J. Lin, M.L. Xiao, H.J. Niu, B. Zhang, The spectrum-effect relationship-a rational approach to screening effective compounds, reflecting the internal quality of Chinese herbal medicine. Chin. J. Nat. Med. 14(3), 177–184 (2016)PubMed
5.
G.L. Xu, M. Xie, X.Y. Yang, Y. Song, C. Yan, Y. Yang, X. Zhang, Z.Z. Liu, Y.X. Tian, Y. Wang, R. Jiang, W.R. Liu, X.H. Wang, G.M. She, Spectrum-effect relationships as a systematic approach to traditional Chinese medicine research: current status and future perspectives. Molecules 19(11), 17897–17925 (2014)PubMedPubMedCentralCrossRef
6.
W. Qiang, L. Kemin, Research progress on spectrum-effect relationship of traditional Chinese medicine. Tradit. Chin. Drug Res. Clin. Pharmacol. 30(5), 634–638 (2019)
7.
L. Cai, Q. Zhang, F.Q. Yang, Applications progress on spectrum-effect relationship in study of Chinese materia medica. Chin. Tradit. Herb. Drugs 48(23), 5005–5011 (2017)
8.
L.J. Wang, Z.M. Jiang, P.T. Xiao, J.B. Sun, Z.M. Bi, E.H. Liu, Identification of anti-inflammatory components in Sinomenii Caulis based on spectrum-effect relationship and chemometric methods. J. Pharm. Biomed. Anal. 167, 38–48 (2019)PubMedCrossRef
9.
Y.L. Wang, Q. Zhang, S.J. Yin, L. Cai, Y.X. Yang, W.J. Liu, Y.J. Hu, H. Chen, F.Q. Yang, Screening of blood-activating active components from Danshen-Honghua herbal pair by spectrum-effect relationship analysis. Phytomedicine 54, 149–158 (2019)PubMedCrossRef
10.
J.D. Zhang, T. Chen, K. Li, H.Y. Xu, R.X. Liang, W.H. Wang, H. Li, A.J. Shao, B. Yang, Screening active ingredients of rosemary based on spectrum-effect relationships between UPLC fingerprint and vasorelaxant activity using three chemometrics. J. Chromatogr. B 1134, 121854 (2019)CrossRef
11.
Y. Chen, J. Liang, W. Dong, F. Li, J.H. Dong, L. Cao, J.B. Yuan, Preliminary study of antiemetic components in Euodia rutaecarpa based on spectrum-effect correlation analysis. Yaoxue Xuebao 52(11), 1737–1742 (2017)
12.
Y. Chen, C.M. Wu, R.J. Dai, L. Li, Y.H. Yu, Y. Li, W.W. Meng, L. Zhang, Y. Zhang, Y.L. Deng, Combination of HPLC chromatogram and hypoglycemic effect identifies isoflavones as the principal active fraction of Belamcanda chinensis leaf extract in diabetes treatment. J. Chromatogr. B 879(5–6), 371–378 (2011)CrossRef
13.
Z.M. Chen, L. Quan, H.T. Zhou, Y.F. Zhao, P. Chen, L. Hu, Z. Yang, C.J. Hu, D. Cao, Screening of active fractions from Curcuma Longa Radix isolated by HPLC and GC-MS for promotion of blood circulation and relief of pain. J. Ethnopharmacol. 234, 68–75 (2019)PubMedCrossRef
14.
J. Gao, X. Li, Y. Zhou, H.F. Pan, Study on spectrum-effect relationship among effects of different extracts of Crataegi Folium on whole blood viscosity in rats. Chin. Tradit. Herb. Drugs 49(6), 1385–1389 (2018)
15.
Y.Y. Geng, C.J. Hu, X. Pan, L. Zhao, R. Xiong, L. Zhang, L. Hu, Spectrum-effect relationship of different parts from Ershen Pill on warming spleen to relieve diarrhea. Chin. Tradit. Herb. Drugs 45(18), 2658–2663 (2014)
16.
Q.L. Guo, T.H. Zhang, N. Wang, G.W. Zhou, H.B. Luo, Z.S. Huang, Spectrum-effect relationship of inhibition of different extracted parts from Lepdium meyenii on PDE5 activity. Chin. Tradit. Herb. Drugs 48(4), 728–736 (2017)
17.
Q. He, C. Tu, J.B. Wang, Z.J. Liu, M.C. Sha, L. Zhang, C.Y. Li, X.H. Xiao, Antiplatelet aggregation bioactivity of Polygoni Multiflori Radix with chemical fingerprints and spectrum-effect correlation analysis. China J. Chin. Materia Med. 42(9), 1679–1684 (2017)
18.
L. Hu, J. Zhang, L. Lin, S. Liao, Z. Yan, G. Xu, Y. Li, A study on the antibacterial material basis of polygonum capitatum by spectrum-effect relationship. China J. Chin. Materia Med. 39(9), 2037–2040 (2016)
19.
S.X. Huo, Y.T. Kang, X.M. Peng, L. Gao, M. Yan, Spectrum-effect relasionship of extract from rhizome of Alpinia officinarum on promotion of melanogenesis. Chin. Tradit. Herb. Drugs 44(8), 995–1002 (2013)
20.
J.J. Li, M. Yu, Y. Gao, T. Zhang, H.M. Jia, H.W. Zhang, Z.M. Zou, Anti-inflammatory active ingredient of Chinese Herb Polygoni Cuspidati Rhizoma based on spectrum-effect relationship. Chin. J. Exp. Tradit. Med. Formulae 25(12), 208–213 (2019)
21.
L.L. Li, N.N. Ma, S.S. Fan, J. Ma, C.S. Yang, H. Guo, L.L. Song, P.W. Zhuang, Therapeutic effects and spectra-effect relationship of different extracts of Eucommia ulmoides on Parkinson’s disease mice. Chin. Tradit. Herb. Drugs 50(6), 1400–1406 (2019)
22.
Z. Li, L. Zhou, G. Dawuti, S. Aibai, Grey relational analysis on fingerprint characteristics of different eluted parts of Euphorbia humifusa and antifungal effect. Zhongguo Zhongyao Zazhi 37(5), 580–584 (2012)PubMed
23.
J. Liang, Y. Chen, G. Ren, W. Dong, M. Shi, L. Xiong, J. Li, J. Dong, F. Li, J. Yuan, Screening hepatotoxic components in euodia rutaecarpa by UHPLC-QTOF/MS based on the spectrum-toxicity relationship. Molecules 22(8), 1264 (2017)PubMedPubMedCentralCrossRef
24.
M.Y. Lin, Y.P. Zhang, Y. Li, M. Jiang, P.W. Zhuang, Y.J. Zhang, L.L. Song, Spectra-effect relationship of anti-inflammation of Salvia miltiorrhiza extract based on gray correlation analysis. Chin. Tradit. Herb. Drugs 48(16), 3447–3452 (2017)
25.
M. Liu, Y.Y. Huang, M.Y. Lin, C.L. Wang, X. Li, N.N. Ma, Y.J. Zhang, L.L. Song, M.X. Zhang, Experimental studies on anti-fatigue effects and spectra-effect relationship of different extracts from black Lepidium meyenii (Maca). Chin. Tradit. Herb. Drugs 49(9), 2090–2096 (2018)
26.
N.N. Ma, X. Li, H. Jin, L.Y. Ding, X.X. Yan, D.H. Yan, Y.Y. Sheng, Z. Yang, L.L. Song, Spectrum-effect relationship and mechanism of anti-inflammatory effects of different extracts of Corydalis yanhusuo. Chin. Tradit. Herb. Drugs 50(10), 2413–2419 (2019)
27.
M.R. Xiang, X.X. Wang, Q.H. Sun, L.L. Gong, Y. Yang, R. Rong, Spectrum-activity relationships between HPLC fingerprints and analgesic and anti-inflammatory activities of Asari Radix Et Rhizoma different extracts. Liaoning J. Tradit. Chin. Med. 43(12), 2603–2607 (2016)
28.
H. Nie, H. Zhang, X.Q. Zhang, Y. Luo, L.Z. Meng, Z. Yin, J. Zhang, K. Li, A.H. Xiong, L. Zhong, H. Huang, W.C. Ye, Relationship between HPLC fingerprints and invivo pharmacological effects of a traditional Chinese medicine: Radix Angelicae Dahuricae. Nat. Prod. Res. 25(1), 53–61 (2011)PubMedCrossRef
29.
S.Y. Wu, Z.L. Wen, X. Xia, C.Y. Liang, D.D. Yang, X.X. Wang, Relationship between spectrum and antitussive effect of total alkaloids from Stemona Tuberosa. J. Chin. Med. Mater. 3, 515–519 (2019)
30.
B.X. Xu, J. Gao, S.N. Zhao, Y.R. Li, Y.L. Du, H.F. Pan, The spectrum-effect relationship between HPLC fingerprint and the invigorating blood and dissolving stasis effect of Hawthorn leaves. Chromatographia 83, 409–421 (2020)CrossRef
31.
Q.C. Zang, J.B. Wang, W.J. Kong, C. Jin, Z.J. Ma, J. Chen, Q.F. Gong, X.H. Xiao, Searching for the main anti-bacterial components in artificial Calculus bovis using UPLC and microcalorimetry coupled with multi-linear regression analysis. J. Sep. Sci. 34(23), 3330–3338 (2011)PubMedCrossRef
32.
T.T. Zhu, L. Wu, X.L. Wang, H. Zhu, X.C. Zhu, Q.G. Zhou, X. Liu, B.C. Cai, Investigation on relationships between chemical spectrum and bioeffect of prepared rhubarb decoction in rats by UPLC-ESI-Q-TOF-MS method coupled with gray correlation analysis. J. Funct. Foods 31, 104–112 (2017)CrossRef
33.
T. Liu, H.D. Wang, L.Q. Di, A. Kang, X.L. Zhao, X.X. Zhu, J.S. Li, HPLC specific chromatogram spectrum-effect relationship for Shuanghuanglian on MDCK cell injury induced by influenza A virus (H1N1). China J. Chin. Materia Med. 40(21), 4194–4199 (2015)
34.
Y. Zhao, X.M. You, H. Jiang, G.X. Zou, B. Wang, Spectrum–effect relationships between high-performance liquid chromatography fingerprints and anti-inflammatory activities of Leontopodium leontopodioides (Willd.) Beauv. J. Chromatogr. B 1104, 11–17 (2019)
35.
L. Yang, H. Jiang, S. Wang, A.J. Hou,W.J. Man, J.X. Zhang, X.Y. Guo, B.Y. Yang, H.X. Kuang, Q.H. Wang, Discovering the major antitussive, expectorant, and anti-inflammatory bioactive constituents in Tussilago farfara L. based on the spectrum-effect relationship combined with chemometrics. Molecules 25(3), 620 (2020)
36.
M. Liao, P. Yan, X.C. Liu, Z.F. Du, S.L. Jia, R. Aybek, A.Q. Li, S. Kaisa, H.L. Jiang, Spectrum-effect relationship for anti-tumor activity of shikonins and shikonofurans in medicinal Zicao by UHPLC-MS/MS and chemometric approaches. J. Chromatogr. B 1136, 121924 (2020)CrossRef
37.
R.S. Ibrahim, A. Khairy, H.H. Zaatout, H.M. Hammoda, A.M. Metwally, A.M. Salman, Chemometric evaluation of alfalfa sprouting impact on its metabolic profile using HPTLC fingerprint-efficacy relationship analysis modelled with partial least squares regression. J. Pharm. Biomed. Anal. 179, 112990 (2020)PubMedCrossRef
38.
Q. Fan, R.J. Yang, F.X. Yang, P.F. Xia, L. Zhao, Spectrum-effect relationship between HPLC fingerprints and antioxidant activity of Angelica sinensis. Biomed. Chromatogr. 34(2), e4707 (2020)PubMedCrossRef
39.
Y.R. Chen, S.H. Zou, W.F. Xu, Q.W. Sun, L. Yun, Spectrum-effect relationship of antioxidant and anti-inflammatory activities of Laportea bulbifera based on multivariate statistical analysis. Biomed. Chromatogr. 34(2), e4734 (2020)PubMedCrossRef
40.
X.W. Zhou, Y. Li, M.Y. Zhang, J.J. Hao, Q. Gu, H.Y. Liu, W. Chen, Y.F. Shi, B. Dong, Y.Y. Zhang, C.Y. Li, G.H. Li, Spectrum-effect relationship between UPLC fingerprints and antilung cancer effect of Si Jun Zi Tang, Evid.-Based Complement. Alternat. Med. 7282681 (2019)
41.
H.Y. Liu, S. Zhu, Q. Liu, Y.Q. Zhang, Spectrum-effect relationship study between HPLC fingerprints and antioxidant of honeysuckle extract. Biomed. Chromatogr. 33(10), e4583 (2019)PubMedCrossRef
42.
Z.F. Hou, G.X. Sun, Y. Guo, F.L. Yang, D.D. Gong, Capillary electrophoresis fingerprints combined with linear quantitative profiling method to monitor the quality consistency and predict the antioxidant activity of Alkaloids of Sophora flavescens. J. Chromatogr. B 1133, 121827 (2019)CrossRef
43.
T.T. Dai, F.L. Yang, J.D. Liu, G.X. Sun, Evaluation of the quality consistency of Zhenju Jiangya tablets by systematic quantified fingerprint method in combination with antioxidant activity and three compounds analyses. Microchem. J. 150, 104175 (2019)CrossRef
44.
C.H. Chen, J.L. Chen, J.J. Shi, S.Y. Chen, H. Zhao, Y. Yan, Y.C. Jiang, L. Gu, F.Y. Chen, X.H. Liu, A strategy for quality evaluation of salt-treated Apocyni Veneti Folium and discovery of efficacy-associated markers by fingerprint-activity relationship modeling. Sci. Rep. 9(1), 16666 (2019)PubMedPubMedCentralCrossRef
45.
C.C. Zou, H.Y. Yan, L.L. Wang, Y.Y. Bian, Screening and validation of antithrombotic effective components group from Trichosanthes extract. Yaoxue Xuebao 54(3), 502–509 (2019)
46.
Z. Zhang, L. Chen, X. Cui, Y. Zhang, Y. Hu, C. Wang, Y. Xiong, Identification of anti-inflammatory components of raw and steamed: Panax notoginseng root by analyses of spectrum-effect relationship. RSC Adv. 9(31), 17950–17958 (2019)PubMedPubMedCentralCrossRef
47.
Y.J. Zhang, F.L. Yang, J. Zhang, G.X. Sun, C. Wang, Y. Guo, R. Wen, W.Y. Sun, Quantitative fingerprint and quality control analysis of compound Liquorice tablet combined with antioxidant activities and chemometrics methods. Phytomedicine 59, 152790 (2019)PubMedCrossRef
48.
Y.J. Zhang, C. Wang, F.L. Yang, G.X. Sun, A strategy for qualitative and quantitative profiling of glycyrrhiza extract and discovery of potential markers by fingerprint-activity relationship modeling. Sci. Rep. 9(1), 1309 (2019)PubMedPubMedCentralCrossRef
49.
L.F. Yang, B.N. Zhao, X.Y. Ding, Q.H. Sun, J. Lv, Y. Gao, Spectrum-effect relationship of angiogenesis activity and cardioprotection of water-soluble components of Salvia miltiorrhiza in zebrafish. Chin. Tradit. Herb. Drugs 50(12), 2899–2907 (2019)
50.
F.L. Yang, Y.J. Zhang, Y. Yu, Q.N. Gao, G.X. Sun, Quality assessment of licorice extract powder through geometric linear quantified fingerprint method combined with multicomponent quantification and chemometric analysis. Microchem. J. 146, 239–249 (2019)CrossRef
51.
Z.W. Xiao, M.Z. Xie, L. Gan, M.Y. Fang, X.Y. Zhou, Y.M. Zhou, W. He, L. Chen, J.H. Huang, Determination of chlorogenic acid, total flavones, and anti-oxidant activity of Flos Lonicerae Japonicae and Flos Lonicerae. Chin. Tradit. Herb. Drugs 50(1), 210–216 (2019)
52.
T.G. Xie, J.M. Chen, Y.J. Li, B.Q. Lan, Z.O. Jiang, Spectrum-effect relationship of Dendrobium officinale with phagocytosis of macrophages in mice with hypoimmunity. Guangxi Med. J. 41(11), 1398–1401+1423 (2019)
53.
S. Song, L.Y. Gu, J.G. Xu, X.B. Cui, S.L. Du, W.D. Li, UFLC-Q-TOF-MS fingerprints of rhizome of Curcuma phaeocaulis and its vinegar processed products and inhibitory effect on thrombosis. China J. Chin. Materia Med. 44(12), 2511–2518 (2019)
54.
L.H. Qu, G.S. Cao, J.Y. Tu, K. Shi, J. Wang, Y.Y. Xu, Y.J. Liu, Spectrum-effect relationship of dryness of Atractylodis Rhizoma volatile oil based on grey relational grade and orthogonal partial least squares analysis. Chin. Tradit. Herb. Drugs 50(1), 150–156 (2019)
55.
Y.L. Yang, F. Cui, F. Hu, L. Guo, T. Yang, Y.D. Li, S.L. Feng, Investigation on chromatogram-pharmacodynamics relationship of Angelica sinensis on effect of replenishing blood. Zhongguo Zhongyao Zazhi 38(22), 3923–3927 (2013)PubMed
56.
W.L. Li, J.X. Ding, J. Bai, Y. Hu, H. Song, X.M. Sun, Y.B. Ji, Research on correlation of compositions with oestrogenic activity of Cistanche based on LC/Q-TOF-MS/MS technology. Open Chem. 17(1), 1–12 (2019)CrossRef
57.
W. Li, Y. Zhang, S. Shi, G. Yang, Z. Liu, J. Wang, W. Kang, Spectrum-effect relationship of antioxidant and tyrosinase activity with Malus pumila flowers by UPLC-MS/MS and component knock-out method. Food Chem. Toxicol. 133, 110754 (2019)PubMedCrossRef
58.
C. Li, C. Tu, Y. Che, M. Zhang, B. Dong, X. Zhou, Y. Shi, G. Li, J. Wang, Bioassay based screening for the antiplatelet aggregation quality markers of Polygonum multiflorum with UPLC and chemometrics. J. Pharm. Biomed. Anal. 166, 264–272 (2019)PubMedCrossRef
59.
X.C. Gao, J.W. Lv, C.N. Li, N.X. Zhang, L.L. Tian, X.Y. Han, H. Zhang, J.M. Sun, Screening of the active component promoting Leydig cell proliferation from Lepidium meyenii using HPLC-ESI-MS/MS coupled with multivariate statistical analysis. Molecules 24(11), 2101 (2019)PubMedPubMedCentralCrossRef
60.
Y. Feng, Z. Jing, Y. Li, S. Lv, W. Li, G. Cai, D. Yang, Y. Wang, Screening anaphylactoid components of Shuang Huang Lian Injection by analyzing spectrum–effect relationships coupled with UPLC–TOF–MS. Biomed. Chromatogr. 33(2), e4376 (2019)PubMedCrossRef
61.
X.Y. Chen, S.H. Gou, Z.Q. Shi, Z.Y. Xue, S.L. Feng, Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat. J. Pharmaceut. Anal. 9(4), 266–273 (2019)
62.
H. Cai, Y. Xu, L. Xie, Y. Duan, J. Zhou, J. Liu, M. Niu, Y. Zhang, L. Shen, K. Pei, G. Cao, Investigation on spectrum-effect correlation between constituents absorbed into blood and bioactivities of baizhu shaoyao san before and after processing on ulcerative colitis rats by UHPLC/Q-TOF-MS/MS coupled with gray correlation analysis. Molecules 24(5), 940 (2019)PubMedPubMedCentralCrossRef
63.
Y. Zhang, C. Wang, F. Yang, Z. Yang, F. Wang, G. Sun, UHPLC-ESI-Q-TOF-MS/MS analysis, antioxidant activity combined fingerprints for quality consistency evaluation of compound liquorice tablets. RSC Adv. 8(49), 27661–27673 (2018)PubMedPubMedCentralCrossRef
64.
X.F. Zhang, J. Chen, J.L. Yang, Y.P. Shi, UPLC-MS/MS analysis for antioxidant components of Lycii Fructus based on spectrum-effect relationship. Talanta 180, 389–395 (2018)PubMedCrossRef
65.
B. Yan, G.X. Sun, Monitoring quality consistency of Liuwei Dihuang Pill by integrating the ultraviolet spectroscopic fingerprint, a multi-wavelength fusion fingerprint method, and antioxidant activities. J. Sep. Sci. 41(6), 1182–1191 (2018)PubMedCrossRef
66.
X.Y. Xue, C.X. Liu, J.R. Wang, L.M. Xie, J.W. Tang, Y.G. Yao, L.Y. Zhang, Y. Zhou, Spectrum-effect relationship of anti-inflammatory effect of different part from Polygonum capitatum. Chin. Tradit. Herb. Drugs 49(21), 5134–5141 (2018)
67.
X. Xiong, Y.N. He, B. Feng, Y. Pan, H.Z. Zhang, X.M. Ke, Y. Zhang, M. Yang, L. Han, D.K. Zhang, Screening for the anti-inflammation quality markers of Xiaojin Pills based on HPLC-MS/MS method, COX-2 inhibition test and protein interaction network. Sci. Rep. 8(1), 7454 (2018)PubMedPubMedCentralCrossRef
68.
R.Y. Xiao, L.J. Wu, X.X. Hong, L. Tao, P. Luo, X.C. Shen, Screening of analgesic and anti-inflammatory active component in Fructus Alpiniae zerumbet based on spectrum–effect relationship and GC–MS. Biomed. Chromatogr. 32(3), e4112 (2018)CrossRef
69.
Y.L. Wang, G. Hu, Q. Zhang, Y.X. Yang, Q.Q. Li, Y.J. Hu, H. Chen, F.Q. Yang, Screening and Characterizing Tyrosinase Inhibitors from Salvia miltiorrhiza and Carthamus tinctorius by Spectrum-Effect Relationship Analysis and Molecular Docking. J. Anal. Methods Chem. 2141389 (2018)
70.
Y. Wang, W. Liu, D. Yang, Y. Qing, P. Du, Y. Jin, X. Yao, Establishment of fingerprint of Gegen Qinlian decoction and its formula compatibility groups using UHPLC–MS/MS and its study to spectrum–effect relationship. J. Liq. Chromatogr. Relat. Technol. 41(7), 384–390 (2018)CrossRef
71.
S.N. Wang, Y.S. Ding, X.J. Ma, C.B. Zhao, M.X. Lin, J. Luo, Y.N. Jiang, S. He, J.Y. Guo, J.L. Shi, Identification of bioactive chemical markers in Zhi zhu xiang improving anxiety in rat by fingerprint-efficacy study. Molecules 23(9), 2329 (2018)PubMedPubMedCentralCrossRef
72.
J. Wang, D. Luo, M. Liang, T. Zhang, X. Yin, Y. Zhang, X. Yang, W. Liu, Spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and the antioxidant and anti-inflammatory activities of collagen peptides. Molecules 23(12), 3257 (2018)PubMedPubMedCentralCrossRef
73.
S. Song, W.F. Yao, X.B. Cui, X. Liu, R.L. Qiu, Spectrum-effect relationship analysis by binary chromatographic fingerprint to identify components responsible for the antibacterial activity of the essential oil from curcumae wenyujin. Int. J. Food Prop. 21(1), 546–556 (2018)CrossRef
74.
C.Y. Shu, Y.C. Zhu, K.M. Qin, B.C. Cai, Study on spectrum-effect relationship of anti-inflammatory active of Yinqiaosan decoction at different decoct times. Chin. J. Tradit. Chin. Med. 33(9), 4161–4166 (2018)
75.
W. Shi, C. Zhang, D.S. Zhao, L.L. Wang, P. Li, H.J. Li, Discovery of hepatotoxic equivalent combinatorial markers from Dioscorea bulbifera tuber by fingerprint-toxicity relationship modeling. Sci. Rep. 8(1), 462 (2018)PubMedPubMedCentralCrossRef
76.
M. Shi, Y. Zhang, M. Song, Y. Sun, C. Li, W. Kang, Screening the marker components in psoralea corylifolia l. With the aids of spectrum-effect relationship and component knock-out by UPLC-MS2. Int. J. Mol. Sci. 19(11), 3439 (2018)
77.
C.H. Shen, C.T. Liu, X.J. Song, W.Y. Zeng, X.Y. Lu, Z.L. Zheng, P. Jie, R.T. Zhan, Y. Ping, Evaluation of analgesic and anti-inflammatory activities of Rubia cordifolia L. by spectrum-effect relationships. J. Chromatogr. B, 1090, 73–80 (2018)
78.
E. Shawky, R.S. Ibrahim, Bioprofiling for the quality control of Egyptian propolis using an integrated NIR-HPTLC-image analysis strategy. J. Chromatogr. B-Analyt. Technol. Biomed. Life Sci. 1095, 75–86 (2018)PubMedCrossRef
79.
S.M. Shan, J.G. Luo, F. Huang, L.Y. Kong, Chemical characteristics combined with bioactivity for comprehensive evaluation of Panax ginseng CA Meyer in different ages and seasons based on HPLC-DAD and chemometric methods. J. Pharm. Biomed. Anal. 89, 76–82 (2014)PubMedCrossRef
80.
Y.Y. Liu, X.R. Chen, L.F. Gao, M. Chen, W.Q. Cui, W.Y. Ding, X.Y. Chen, B.O. God'spower, Y.H. Li, Spectrum-effect relationships between the bioactive ingredient of Syringa oblata Lindl. Leaves and its role in inhibiting the biofilm formation of Streptococcus suis. Front. Pharmacol. 9, 570 (2018)
81.
X. Liu, X. Wang, T. Zhu, H. Zhu, X. Zhu, H. Cai, G. Cao, X. Xu, M. Niu, B. Cai, Study on spectrum-effect correlation for screening the effective components in Fangji Huangqi Tang basing on ultra-high performance liquid chromatography-mass spectrometry. Phytomedicine 47, 81–92 (2018)PubMedCrossRef
82.
M. Liu, Y. Wu, S. Huang, H. Liu, J. Feng, Spectrum–effect relationship between HPLC fingerprints and hypolipidemic effect of Curcuma aromatica. Biomed. Chromatogr. 32(7), e4220 (2018)PubMedCrossRef
83.
Q. Li, H. Bao, T. Bau, Y. Li, Influence of Inonotus hispidus in hemorheology in rat model with blood stasis due to cold syndrome and analysis on spectral efficiency. J. Jilin Univ. Med. Ed. 44(1), 30–35 (2018)
84.
J.L. Wang, W.Y. Guo, Spectrum-effect relationships on sedative and hypnotic effect of new Yixin Ningshen tablet. Chinese Materia Medica 40(7), 1633–1637 (2017)
85.
Z. Jiang, C. Zhao, X. Gong, X. Sun, H. Li, Y. Zhao, X. Zhou, Quantification and efficient discovery of quality control markers for Emilia prenanthoidea DC. by fingerprint-efficacy relationship modelling. J. Pharmaceut. Biomed. Anal. 156, 36–44 (2018)
86.
X. Gao, Y.L. Ma, Z.W. Wang, R.B. Bia, P. Zhang, F.D. Hu, Identification of anti-inflammatory active ingredients from Tumuxiang by ultra-performance liquid chromatography/quadrupole time-of-flight-MSE. Biomed. Chromatogr. 32(5), e4179 (2018)PubMedCrossRef
87.
J. Feng, X. Mao, S. Huang, S. Chen, H. Liu, Infrared fingerprints-based mathematical modeling for characterization of different regions of Zanthoxylum nitidum (Roxb.) DC and prediction of inhibitory components on liver cells. Spectrosc. Lett. 51(7), 382–388 (2018)
88.
L. Cui, N. He, X. Zhang, S. Li, Y. Zhang, W. Kang, Dynamic change of secondary metabolites and spectrum-effect relationship of Malus halliana Koehne flowers during blooming. Open Chem. 16(1), 362–370 (2018)CrossRef
89.
Z. Chen, X. Du, Y. Yang, X. Cui, Z. Zhang, Y. Li, Comparative study of chemical composition and active components against α-glucosidase of various medicinal parts of Morus alba L. Biomed. Chromatogr. 32(11), e4328 (2018)PubMedCrossRef
90.
Y. Chen, Z.Y. Xue, Z.Q. Shi, Y.F. Yang, X.Y. Yang, L.G. Zhao, S.L. Feng, Spectrum-effect relationship of active fraction from Hedysarum polybotrys on osteoporosis. Chin. Tradit. Herb. Drugs 49(1), 160–166 (2018)
91.
Z.Y. Wang, Y. Li, H.E. Yao, J. Luo, C.Q. Li, M. Zhang, X.J. Xie, Study on the spectrum- effect relationship of ginsenoside regulating expression of HIF-1α under AGEs based on retinal Müller cells. Pharmacol. Clin. Chin. Materia Medica 33(02), 91–95 (2017)
92.
L.M. Zhuo, J.J. Peng, Y.L. Zhao, D.X. Li, X.M. Xie, L. Tong, Z.G. Yu, Screening bioactive quality control markers of QiShenYiQi dripping pills based on the relationship between the ultra-high performance liquid chromatography fingerprint and vascular protective activity. J. Sep. Sci. 40(20), 4076–4084 (2017)PubMedCrossRef
93.
Y.J. Zhang, L.P. Yang, J. Zhang, M. Shi, G.X. Sun, Micellar electrokinetic capillary chromatography fingerprints combined with multivariate statistical analyses to evaluate the quality consistency and predict the fingerprint-efficacy relationship of Salviae miltiorrhizae Radix et Rhizoma (Danshen). J. Sep. Sci. 40(13), 2800–2809 (2017)PubMedCrossRef
94.
C.P. Zhang, X.G. Shen, J.W. Chen, X.S. Jiang, F.L. Hu, Identification of free radical scavengers from Brazilian green propolis using off-line HPLC-DPPH assay and LC-MS. J. Food Sci. 82(7), 1602–1607 (2017)PubMedCrossRef
95.
Y.L. Wang, W. Liu, D.B. Yang, Y.J. Qin, P. Du, Research on spectrum-effect relationship of Scutellaria baicalensis Georgi. Chin. Arch. Tradit. Chin. Med. 35(12), 3110–3113 (2017)
96.
B. Yan, L.P. Yang, D.D. Ma, G.X. Sun, Comprehensively evaluating the quality consistency of Liuwei Dihuang Pill by five-wavelength overall fused HPLC fingerprints combined with simultaneous determination and antioxidant activity. J. Chromatogr. Sci. 55(10), 1026–1036 (2017)PubMedCrossRef
97.
S.N. Wu, Z.J. Liu, C.E. Zhang, Q. He, X. Wang, M. Niu, J.B. Wang, X.H. Xiao, Study on antiplatelet aggregation active components of Erigeron breviscapus in vitro based on spectrum-effect correlation analysis. Chin. Tradit. Herb. Drugs 48(24), 5179–5185 (2017)
98.
Y. Wang, G.X. Sun, Y. Jin, X.M. Xie, Y.C. Liu, D.D. Ma, J. Zhang, J.Y. Gao, Y.F. Li, Holistic evaluation of San-Huang tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays. Chin. J. Nat. Med. 15(4), 310–320 (2017)PubMed
99.
Y. Wang, Y. Li, Y. Zhang, G. Feng, Z. Yang, Q. Guan, R. Wang, F. Han, Multi-dimensional spectrum-effect relationship of the impact of Chinese herbal formula lichong shengsui yin on ovarian cancer. Molecules 22(6), 979 (2017)PubMedPubMedCentralCrossRef
100.
L. Wang, T. Yan, L.P. Yang, K.X. Zhang, J.M. Jia, Monitoring the consistency quality and antioxidant activity of Da Hong Pao Teas by HPLC fingerprinting. J. Chromatogr. Sci. 55(5), 528–535 (2017)PubMedCrossRef
101.
J.M. Wang, C. Yao, C.Q. Li, W.Y. Kang, Spectrum-effect relation of antioxidant activity of Flos Carthami based on DPPH, ABTS and FRAP assay. Chin. Pharm. J. 52(10), 825–831 (2017)
102.
J. Wang, L. Peng, M. Shi, C. Li, Y. Zhang, W. Kang, Spectrum effect relationship and component knock-out in Angelica Dahurica Radix by high performance liquid chromatography-Q exactive hybrid quadrupole-orbitrap mass spectrometer. Molecules 22(7), 1231 (2017)PubMedPubMedCentralCrossRef
103.
M. Shi, G.X. Sun, Integrated evaluation of HPLC and UV fingerprints for the quality control of Danshen tablet by systematic quantified fingerprint method combined with antioxidant activity. J. Sep. Sci. 40(9), 1942–1952 (2017)PubMedCrossRef
104.
F. Shao, L.F. Gu, D.D. Zhong, R.H. Liu, H.P. Zhao, H.L. Huang, M. Yang, Spectrum-effect relationship of triglyceride-lowering fraction of Crataegus pinnatifida fruit. Chin. Tradit. Herb. Drugs 48(2), 339–344 (2017)
105.
Y.J. Qing, W. Liu, P. Du, Y. Jin, X.Y. Yao, Spectrum-effect relationship for inhibitory action of Wuji Pills on pepsin based on grey incidence degree method. Chin. Tradit. Herb. Drugs 48(16), 3390–3395 (2017)
106.
D.D. Ma, L.P. Yang, B. Yan, G.X. Sun, Capillary electrophoresis fingerprints combined with chemometric methods to evaluate the quality consistency and predict the antioxidant activity of Yinqiaojiedu tablet. J. Sep. Sci. 40(8), 1796–1804 (2017)PubMedCrossRef
107.
S. Lv, S. Dong, D. Xu, J. Duan, G. Li, Y. Guo, H. Kuang, Q. Wang, Spectrum-effect relationships between fingerprints of caulophyllum robustum maxim and inhabited pro-inflammation cytokine effects. Molecules 22(11), 1826 (2017)CrossRef
108.
Y. Li, M. Xu, H.F. Chen, M. Wang, M. Zhang, X.J. Xie, Spectrum-effect relationship of Salvia miltiorrhiza extract on HIF-1α of retinal Müller cells in AGEs or hypoxia conditions. Chin. Tradit. Herb. Drugs 48(11), 2231–2236 (2017)
109.
Q. Li, H. Guan, X. Wang, Y. He, H. Sun, W. Tan, X. Luo, M. Su, Y. Shi, Fingerprint–efficacy study of the quaternary alkaloids in Corydalis yanhusuo. J. Ethnopharmacol. 207, 108–117 (2017)PubMedCrossRef
110.
M.F. Li, Y. Du, L. Wang, L.L. Jiang, X.D. Ma, P. Zhou, P. Li, H.J. Li, Efficient discovery of quality control markers for Gastrodia elata tuber by fingerprint-efficacy relationship modelling. Phytochem. Anal. 28(4), 351–359 (2017)PubMedCrossRef
111.
K. Li, Y. Gao, B. Wang, L. Lv, B. Zhao, H. Zhao, Grey relational analysis and LS-SVM modeling for the fingerprint-efficacy study of Yinhuang granules, in 2016 International Conference on Advanced Mechatronic Systems. IEEE, pp. 344–349 (2016)
112.
Y.B. Jiang, M. Zhong, M.X. Hu, L. Chen, Y. Gou, J. Zhou, P.E. Wu, Y.Y. Ma, Spectrum-effect relationships between high performance liquid chromatography fingerprint and Analgesic property of anisodus tanguticus (Maxim) pascher (Solanaceae) roots. Trop. J. Pharm. Res. 16(2), 379–386 (2017)CrossRef
113.
Y. Hong, X.H. Liu, Y.L. Chen, B. Wang, Y. Chen, Z.Q. Shi, Z.Y. Xue, S.I. Feng, Multi-index integrated evaluation of spectrum-effect relationship on immunocompetence of Radix Astragali. Yaoxue Xuebao 52(5), 785–789 (2017)
114.
J.X. Fan, S. Wang, X.S. Meng, Y.R. Bao, T.J. Li, Study of cancer cell apoptosis induced by Schizonepeta tenuifolia with microfluidic chip technology. Yaoxue Xuebao 52(1), 126–131 (2017)
115.
W.J. Du, J. Ji, L. Wang, X.Y. Lan, J. Li, J.Q. Lei, X. He, C.F. Zhang, W.Z. Huang, Z.Z. Wang, W. Xiao, C.Z. Wang, C.S. Yuan, Relationship between the UPLC-Q-TOF-MS fingerprinted constituents from Daphne genkwa and their anti-inflammatory, anti-oxidant activities. Biomed. Chromatogr. 31(12), e4012 (2017)CrossRef
116.
S. Chen, G.X. Sun, L.P. Yang, J. Zhang, Micellar electrokinetic chromatography fingerprinting combined with chemometrics as an efficient strategy for evaluating the quality consistency and predicting the antioxidant activity of Lianqiao Baidu pills. J. Sep. Sci. 40(13), 2838–2848 (2017)PubMedCrossRef
117.
H.N. Zhou, P.J. Zhang, Z.G. Hou, J.B. Xie, Y.M. Wang, B. Yang, Y.Y. Xu, Y.B. Li, Research on the relationships between endogenous biomarkers and exogenous toxic substances of acute toxicity in radix Aconiti. Molecules 21(12), 1623 (2016)PubMedPubMedCentralCrossRef
118.
X.M. Zhao, S.B. Pu, Q.G. Zhao, M. Gong, J.B. Wang, Z.J. Ma, X.H. Xiao, K.J. Zhao, Preliminary study on effective components of Tripterygium wilfordii for liver toxicity based on spectrum-effect correlation analysis. China J. Chin. Materia Med. 41(15), 2915–2921 (2016)
119.
X.L. Zhang, Y.L. Liu, L.J. Fan, Y.L. Wang, K. Chen, H. Li, Evaluation for extraction process of shenqi tongmai yizhi particles based on antioxidant capacity in vitro and its spectrum-effect relation. China J. Chin. Materia Med. 41(9), 1635–1639 (2016)
120.
Y.L. Ma, Z.Y. Xue, X. Gao, P. Zhang, B.L. Sun, X.P. Zheng, F.D. Hu, Spectrum-effect relationship between Vladimiriae Radix and anti-inflammatory activity based on chemometric methods. Anal. Test. Technol. Instrum. 22(01), 15–22 (2016)
121.
X.H. Yu, P.F. Xia, T. Li, F.L. Liu, Spectrum-effect relationship between mid-infrared spectrum fingerprint of Hedysari Radix and antioxidant capacity in Vitro. Chin. J. Mod. Appl. Pharm. 33(08), 1016–1020 (2016)
122.
N. Yang, A.Z. Xiong, R. Wang, L. Yang, Z.T. Wang, Quality evaluation of traditional Chinese medicine compounds in Xiaoyan Lidan tablets: fingerprint and quantitative analysis using UPLC-MS. Molecules 21(2), 83 (2016)PubMedPubMedCentralCrossRef
123.
L.P. Yang, X.M. Xie, J. Zhang, G.X. Sun, Microemulsion electrokinetic chromatography in combination with chemometric methods to evaluate the holistic quality consistency and predict the antioxidant activity of Ixeris sonchifolia (Bunge) Hance injection. PLoS ONE 11(6), e0157601 (2016)PubMedPubMedCentralCrossRef
124.
L.P. Yang, X.M. Xie, L. Yang, J. Zhang, G.X. Sun, Monitoring quality consistency of Ixeris sonchifolia (Bunge) Hance injection by integrating UV spectroscopic fingerprints, a multi-wavelength fusion fingerprint method, antioxidant activities and UHPLC/Q-TOF-MS. RSC Adv. 6(90), 87616–87627 (2016)CrossRef
125.
L.P. Yang, G.X. Sun, Y. Guo, Z.F. Hou, S. Chen, Holistic evaluation of quality consistency of Ixeris sonchifolia (Bunge) Hance injectables by quantitative fingerprinting in combination with antioxidant activity and chemometric methods. Plos One 11(2) (2016)
126.
B.Y. Yang, M. Li, M. Ren, C.Y. Zhao, H. Wei, L. Peng, Spectrum-effect relationship of antitussive effect by total organic acids in crude and four processed Pinellia ternate based on gray relative analysis method. Chin. Tradit. Herb. Drugs 47(13), 2301–2307 (2016)
127.
D. Yan, W. Peng, Y. Liu, D. Xie, M. Hu, X. Tao, C. Wu, Spectrum-effect relationships between high performance liquid chromatography fingerprints and bioactivities of charred areca nut. Trop. J. Pharm. Res. 15(5), 1017–1024 (2016)CrossRef
128.
X. Liu, Y. Cheng, X.B. Cui, M.C. Li, Spectrum-Effect Study on the Protective Efficacy of Ligusticum Chuanxiong Hort. on Myocardial Ischemia. China Pharmaceut. 25(15), 9–12 (2016)
129.
X. Liu, X. Li, X.B. Cui, M.C. Li, Study of effective substances screening for panax notoginseng based on spectrum-effect relationship. China Pharmacist 19(02), 205–209 (2016)
130.
J.M. Wang, C. Yao, C.C. Lu, C.Q. Li, W.Y. Kang, Spectrum-effect relationship of antioxidant activity of wine fried ligustrum lucidum fructus. Chin. Pharm. J. 51(22), 1907–1912 (2016)
131.
Z. Shi, Z. Liu, C. Liu, M. Wu, H. Su, X. Ma, Y. Zang, J. Wang, Y. Zhao, X. Xiao, Spectrum-effect relationships between chemical fingerprints and antibacterial effects of Lonicerae Japonicae Flos and Lonicerae Flos base on UPLC and microcalorimetry. Front. Pharmacol. 7, 12 (2016)PubMedPubMedCentralCrossRef
132.
M. Shi, W.Y. Sun, G.X. Sun, J. Zhang, Total monitoring of the constituents of Danshen tablet using micellar electrokinetic chromatography fingerprinting for antioxidant activity profiling. J. Sep. Sci. 39(9), 1776–1784 (2016)PubMedCrossRef
133.
X. Liu, X. Li, X.B. Cui, M.C. Li, Screening of bioactive ingredients in Ligusticum Chuanxiong hort for protection against Myocardial Ischemia. Cell. Physiol. Biochem. 40(3–4), 770–780 (2016)PubMedCrossRef
134.
H.Y. Liu, P. Wan, M. Niu, Q. Liu, Y.Q. Zhang, Z.Y. Zhang, Autotoxins screening from aqueous extracts of Salvia Miltiorrhiza Bge. Based on spectrum-effect relationship between HPLC fingerprints and autotoxicity. Pakistan J. Bot. 48(4), 1467–1471 (2016)
135.
W.L. Li, X.M. Sun, B.M. Liu, L.H. Zhang, Z.Q. Fan, Y.B. Ji, Screening and identification of hepatotoxic component in Evodia rutaecarpa based on spectrum-effect relationship and UPLC-Q-TOFMS. Biomed. Chromatogr. 30(12), 1975–1983 (2016)PubMedCrossRef
136.
C.Q. Li, C. Yao, R.Y. Zhu, Y.X. Huang, W.Y. Kang, J.M. Wang, Spectrum-effect relationship in antioxidant activity of Ligustri Lucidi Fructus based on DPPH, ABTS and FRAP assays. Zhongguo Zhongyao Zazhi 41(9), 1670–1677 (2016)PubMed
137.
X.R. Lai, B.H. Zhou, M.S. Du, H.J. Zheng, Z.P. Geng, J.C. Li, X.L. Meng, Y. Zhang, J. Zhang, Determination of six alkaloids in six types of Coptidis Rhizoma pieces by RP-HPLC and spectrum-effect relationships with anti-diabetes pharmacodynamics data. China J. Chin. Materia Med. 41(24), 4579–4586 (2016)
138.
K. Jiang, L. Li, J. Li, G. Yin, J. Wang, Y. Lu, T.J. Wang, The quality evaluation of aerial roots of ficus microcarpa L.f. based on their anti-inflammation activity. Chin. Pharmaceut. J. 51(12), 1033–1038 (2016)
139.
Z.C. Ji, W.Y. Sun, G.X. Sun, J. Zhang, Monitoring the quality consistency of Fufang Danshen Pills using micellar electrokinetic chromatography fingerprint coupled with prediction of antioxidant activity and chemometrics. J. Sep. Sci. 39(15), 3019–3027 (2016)PubMedCrossRef
140.
F. Cui, Z.H. Han, X.H. Liu, Y.F. Yang, Z.H. Lan, S.L. Feng, Spectrum-effect relationship of active fraction from Hedysari Radix on improving immunity. Chin. Tradit Herbal Drugs 47(1), 101–105 (2016)
141.
C.S. Zhu, B. Zhang, Z.J. Lin, X.J. Wang, Y. Zhou, X.X. Sun, M.L. Xiao, Relationship between high-performance liquid chromatography fingerprints and uric acid-lowering activities of Cichorium intybus L. Molecules 20(5), 9455–9467 (2015)PubMedPubMedCentralCrossRef
142.
H. Yan, C. Zou, M. Wei, Y. Yang, F. Fei, X. Xu, Spectrum-effect relationship of GualouXiebai dropping pills on Myocardial Ischemia. J. Chin. Med. Mater. 38(9), 1912–1918 (2015)
143.
R.F. Xie, B.R. Yang, P.P. Cheng, S. Wu, Z.C. Li, J.Y. Tang, S. Li, N. Tang, S.M.Y. Lee, Y.H. Wang, X. Zhou, Study on the HPLC chromatograms and pro-angiogenesis activities of the flowers of Panax notoginseng. J. Liq. Chromatogr. Relat. Technol. 38(13), 1286–1295 (2015)CrossRef
144.
X.D. Wu, H.G. Chen, X. Zhou, Y. Huang, E.M. Hu, Z.M. Jiang, C. Zhao, X.J. Gong, Q.F. Deng, Studies on chromatographic fingerprint and fingerprinting profile-efficacy relationship of Saxifraga stolonifera Meerb. Molecules 20(12), 22781–22798 (2015)PubMedPubMedCentralCrossRef
145.
H.Y. Wu, Y.Y. Xu, Z.Q. Lu, Y.B. Li, Y. Sun, Y.J. Zhang, Spectrum-effect relationship between fingerprint in plasma of Heishunpian and its anti-heart failure effect. Chin. Tradit. Herb. Drugs 46(6), 861–865 (2015)
146.
Y. Tong, X. Zhu, Y. Yan, R. Liu, F. Gong, L. Zhang, J. Hu, L. Fang, R. Wang, P. Wang, The influence of different drying methods on constituents and antioxidant activity of saffron from China. Int. J. Anal. Chem. 5, 953164 (2015)
147.
Y. Nie, Y.Y. Hou, Y.J. Li, X.T. Hou, G. Bai, J.G. Deng, Screening of anti-inflammatory components in Mangiferae Indicae Semen based on bioactivity-integrated UPLC-Q/TOF analysis. Chin. Tradit. Herb. Drugs 46(18), 2743–2749 (2015)
148.
J.Y. Li, X.B. Wang, J.G. Luo, L.Y. Kong, Seasonal variation of alkaloid contents and anti-inflammatory activity of rhizoma coptidis based on fingerprints combined with chemometrics methods. J. Chromatogr. Sci. 53(7), 1131–1139 (2015)PubMedCrossRef
149.
Y. Hu, J. Luo, W. Kong, J. Zhang, A.F. Logrieco, X. Wang, M. Yang, Uncovering the antifungal components from turmeric (Curcuma longa L.) essential oil as Aspergillus flavus fumigants by partial least squares. RSC Adv. 5(52), 41967–41976 (2015)
150.
J. Chi, B. Lin, Z.H. Liu, L.N. Yang, H.T. Song, Spectrum-effect relationship of immunosuppressive activity of Leigongteng Duogan tablet based on partial least squares regression analysis. Chin. Tradit. Herb. Drugs 46(18), 2755–2758 (2015)
151.
J. Chi, B. Lin, Z.H. Liu, L.N. Yang, X.M. Liu, H.T. Song, Fingerprint and spectrum-effect relationships on Tripterygium glycosides preparation. China J. Chin. Materia Med. 40(8), 1479–1483 (2015)
152.
Y. Chen, H. Yu, H. Wu, Y. Pan, K. Wang, L. Liu, Y. Jin, C. Zhang, A novel reduplicate strategy for tracing hemostatic compounds from heating products of the flavonoid extract in platycladi cacumen by spectrum-effect relationships and column chromatography. Molecules 20(9), 16970–16986 (2015)PubMedPubMedCentralCrossRef
153.
Y. Chen, H. Yu, H. Wu, Y. Pan, K. Wang, L. Liu, Y. Jin, C. Zhang, Tracing novel hemostatic compounds from heating products of total flavonoids in Flos Sophorae by spectrum-effect relationships and column chromatography. J. Sep. Sci. 38(10), 1691–1699 (2015)PubMedCrossRef
154.
X. Chen, X. Liu, Y. Chen, Y. Hong, S. Feng, Spectrum-effect relationship on anti-hepatic fibrosis effect of Radix Hedysari. Chin. J. Chromatogr. 33(4), 413–418 (2015)CrossRef
155.
Y. Zhu, Q.F. Zheng, Z.Y. Sun, Z. Chen, Y.L. Zhao, Z.X. Wang, H.Y. Yang, J.Y. Li, Y.G. Li, X.H. Xiao, Fingerprint-efficacy study of Radix Aconiti Lateralis Preparata (Fuzi) in quality control of Chinese herbal medicine. J. Therm. Anal. Calorim. 118(3), 1763–1772 (2014)CrossRef
156.
Q. Zheng, Y. Zhao, J. Wang, T. Liu, B. Zhang, M. Gong, J. Li, H. Liu, B. Han, Y. Zhang, X. Song, Y. Li, X. Xiao, Spectrum-effect relationships between UPLC fingerprints and bioactivities of crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi) and its three processed products on mitochondrial growth coupled with canonical correlation analysis. J. Ethnopharmacol. 153(3), 615–623 (2014)PubMedCrossRef
157.
X.J. Zhang, L.J. Liu, T.T. Song, Y.Q. Wang, X.H. Yang, An approach based on antioxidant fingerprint-efficacy relationship and TLC bioautography assay to quality evaluation of Rubia cordifolia from various sources. J. Nat. Med. 68(2), 448–454 (2014)PubMedCrossRef
158.
C.E. Zhang, Y. Xiong, Q. Dong, D. Gao, L.L. Zhang, L.N. Ma, C. Peng, X.P. Dong, D. Yan, Comparison of reversed-phase liquid chromatography and hydrophilic interaction chromatography for the fingerprint analysis of Radix isatidis. J. Sep. Sci. 37(9–10), 1141–1147 (2014)PubMedCrossRef
159.
M. Yin, Y. Tao, D. Zhu, H.B. Zhang, GC/MS-based dynamic analysis of Eucalyptus camaldulensis extract on correlation of chromatography-activity against Oncomelania hupensis. Chin. J. Schistosomiasis Contr. 26(2), 141–147 (2014)
160.
Y.Z. Xiao, C. Yu, C.Y. Liu, L. Wan, P.H. Xu, J. Han, H.L. Yuan, Spectrum-activity relationship on anti-hepatic fibrosis efficacy of Trionycis Carapax. Chin. Tradit. Herb. Drugs 45(17), 2506–2510 (2014)
161.
S. Xiao, C.Z. Fei, L.F. Zhang, W.L. Zheng, K.Y. Zhang, F.Q. Xue, Spectrum-effect relationship between high performance liquid chromatography fingerprints and anticoccidial activities of a compound Chinese medicine. J. Integr. Agric. 13(5), 1082–1089 (2014)CrossRef
162.
Y. Wang, G.X. Sun, Z.B. Liu, Y.C. Liu, Y.N. Gao, J.Q. Zhang, Z.C. Ji, X.X. Chen, Capillary electrophoresis fingerprinting coupled with chemometrics to evaluate the quality consistency and predict the antioxidant activity of Sanhuang tablet as part of its quality control. J. Sep. Sci. 37(23), 3571–3578 (2014)PubMedCrossRef
163.
X. Wang, L. Jiang, Spectrum-effect relationship between total antioxidant activity and HPLC fingerprint of Arctium lappa Root. J. Chin. Med. Mater. 37(12), 2195–2197 (2014)
164.
H.H. Wang, H.G. Liu, H.X. Huang, L.M. Liu, Q.R. Shen, L.J. Cao, Antihepatoma spectrum-effect relationship of extract from Zanthoxyli Radix. Chin. Tradit. Herb. Drugs 45(8), 1102–1109 (2014)
165.
M. Tang, Y. Ye, Q. Zhang, J. Li, H. Lei, C. Cai, Q. Li, Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury. China J. Chin. Materia Med. 39(22), 4389–4393 (2014)
166.
X.Q. Pan, Y.C. Wu, M.X. Gong, Y.S. Xu, Z.M. Wang, Q.W. Zhang, Y.W. Shang, X.R. Lu, Y.F. Song, Study on pharmacological ingredients of Wuzhuyu Tang treating migraine by correlating absorption ingredients in everted intestinal sac and pharmacodynamics. China J. Chin. Materia Med. 39(1), 126–133 (2014)
167.
X. Liu, X.L. Wang, L. Wu, H. Li, K.M. Qin, H. Cai, K. Pei, T. Liu, B.C. Cai, Investigation on the spectrum-effect relationships of Da-Huang-Fu-Zi-Tang in rats by UHPLC-ESI-Q-TOF-MS method. J. Ethnopharmacol. 154(3), 606–612 (2014)PubMedCrossRef
168.
Y.R. Bao, S. Wang, X.S. Meng, X.X. Yang, Y.L. Cui, Establishment of spectrum-effect relationship network model of qizhiweitong granules promoting gastrointestinal motility. J. Chin. Med. Mater. 37(5), 828–832 (2014)
169.
G.F. Zhang, J. Liu, J. Zhang, Y. Yang, B. Wei, Q.S. Wang, Spectrum-effect relationship of Bupleurum chinense for hepatoprotective effect based on cluster analysis and typical correlation analysis. Chin. Tradit. Herb. Drugs 44(19), 2696–2702 (2013)
170.
Y.L. Yang, F. Hu, X.H. Liu, L. Guo, T. Yang, Y.D. Li, S.L. Feng, Spectrum-effect relationship of active fraction from Angelicae Sinensis Radix with effect of reinforcing Qi. Chin. Tradit. Herb. Drugs 44(23), 3346–3351 (2013)
171.
H.Y. Xu, K. Li, Y.J. Chen, Y.C. Zhang, S.H. Tang, S.S. Wang, D. Shen, X.G. Wang, Y. Lei, D.F. Li, Y. Zhang, L. Jin, H.J. Yang, L.Q. Huang, Study on the absorbed fingerprint-efficacy of Yuanhu Zhitong tablet based on chemical analysis, vasorelaxation evaluation and data mining. PLoS ONE 8(12), e81135 (2013)PubMedPubMedCentralCrossRef
172.
R.F. Xie, X. Zhou, Z.N. Shi, Y.M. Li, Z.C. Li, Study on spectrum-effect relationship of rhizoma rhei, cortex magnoliae officinalis, fructus aurantii immaturus and their formula. J. Chromatogr. Sci. 51(6), 524–532 (2013)PubMedCrossRef
173.
S. Xiao, L.F. Zhang, X. Zhang, S.M. Li, S.M., Xue, F.Q., Tracing antibacterial compounds from Acalypha australis Linn. by spectrum-effect relationships and semi-preparative HPLC. J. Sep. Sci. 36(9–10), 1667–1676 (2013)
174.
Z. Sun, Y. Zhao, T. Liu, X. Sun, R. Li, P. Zhang, X. Xiao, Spectrum-effect relationships between UPLC fingerprints and bioactivities of five Aconitum L. plants. Thermochimica Acta 558, 61–66 (2013)
175.
X.L. Mao, Y. Qin, J. Cai, J.M. Zheng, Y.H. Ye, H.G. Liu, S.S. Huang, Infrared fingerprint of Zathoxylum nitidum and its effect on inhibition of tumor cell. Hongwai Yu Haomibo Xuebao/J. Infrared Millimeter Waves 32(1), 91–96 (2013)CrossRef
176.
P. Luo, Y. Liu, L.Y. Lv, Z.F. Zhang, Spectrum-effect correlation analysis of traditional Tibetan medicine Morina nepalensis on nitric oxide production inhibition. China J. Chin. Materia Med. 38(17), 2882–2885 (2013)
177.
X.Y. Hu, M.H. Liu, Q. Sun, S.J. Zhang, L. Jiang, Spectrum-effect relationship of antibacterial extracts from Isatidis Radix. Chin. Tradit. Herb. Drugs 44(12), 1615–1620 (2013)
178.
X.P. Ding, C.L. Zhang, J. Qi, L.Q. Sun, M.J. Qin, B.Y. Yu, The spectrum-effect integrated fingerprint of Polygonum cuspidatum based on HPLC-diode array detection-flow injection-chemiluminescence. Chin. J. Nat. Med. 11(5), 546–552 (2013)PubMedCrossRef
179.
S.H. Deng, L. Song, X.J. Duan, D.L. Zhang, L. Nie, Correlation analysis between HPLC fingerprint of astragali radix extracts and antifatigue effect. J. Chin. Med. Mater. 36(2), 260–264 (2013)
180.
H.G. Chen, X. Zhou, C. Zhao, S.L. Yang, Z.X. Yi, Dose-response and HPLC spectrum-activity relationships of the anti-inflammatory active site of Kalimeris indica. Chin. Pharm. J. 48(14), 1190–1193 (2013)
181.
G. Zhao, L.X. Peng, S. Wang, Y.B. Hu, L. Zou, HPLC fingerprint-antioxidant properties study of Buckwheat. J. Integr. Agric. 11(7), 1111–1118 (2012)CrossRef
182.
J.M. Zhang, C.M. Fu, Y.C. Hu, Y. Li, S.H. Qing, F. Gao, Screening out potential cardio-toxic components of Chinese herb radix Aconiti Lateralis in rat dosed plasma by high performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. Anal. Lett. 45(12), 1695–1712 (2012)CrossRef
183.
L.Q. Sun, X.P. Ding, J. Qi, H. Yu, S.A. He, J. Zhang, H.X. Ge, B.Y. Yu, Antioxidant anthocyanins screening through spectrum-effect relationships and DPPH-HPLC-DAD analysis on nine cultivars of introduced rabbiteye blueberry in China. Food Chem. 132(2), 759–765 (2012)CrossRef
184.
X.H. Liu, J. Liang, Y. Ren, X.Y. Wei, D.M. Feng, S.L. Feng, Spectrum-effect relationship in effect of improving immunity of astragali radix. J. Chin. Med. Mater. 35(12), 1978–1981 (2012)
185.
X.H. Liu, J. Liang, J.D. Liang, Z.L. Dang, S.L. Feng, Spectrum-effect relationship on anti-gastric ulcer effect of Astragali Radix. Chin. Tradit. Herb. Drugs 43(12), 2448–2452 (2012)
186.
Z. Lin, L. Jing, C. Hui, W. Yong-lin, W. Ai-min, H. Yong, Study on fingerprint-pharmacology correlation of protective effect of Polygonum orientale on myocardial cell oxidative injury induced by H2O2. China J. Chin. Materia Med. 37(17), 2585–2588 (2012)
187.
J.D. Liang, L.G. Zhao, X.H. Liu, W. Li, Z.L. Dang, J. Liang, S.L. Feng, Spectrum-effect relationship of reducing phlegm effect of Peucedanum harrysmithii var. subglabrum. China J. Chin. Materia Medica 37(19), 2894–2897 (2012)
188.
Y. Li, L. Ma, P. Shen, M.X. Gong, Spectrum-effect relationships between HPLC fingerprints and anti-endotoxin activity of chloroform extract from isatidis radix. Chin. Pharm. J. 46(10), 741–744 (2011)
189.
W.J. Kong, J.B. Wang, Q.C. Zang, X.Y. Xing, Y.L. Zhao, W. Liu, C. Jin, Z.L. Li, X.H. Xiao, Fingerprint-efficacy study of artificial Calculus bovis in quality control of Chinese materia medica. Food Chem. 127(3), 1342–1347 (2011)PubMedCrossRef
190.
L.J. Ni, L.G. Zhang, J. Hou, W.Z. Shi, M.L. Guo, A strategy for evaluating antipyretic efficacy of Chinese herbal medicines based on UV spectra fingerprints. J. Ethnopharmacol. 124(1), 79–86 (2009)PubMedCrossRef
191.
W.J. Kong, Y.L. Zhao, X.H. Xiao, J.B. Wang, H.B. Li, Z.L. Li, C. Jin, Y. Liu, Spectrum-effect relationships between ultra performance liquid chromatography fingerprints and anti-bacterial activities of Rhizoma coptidis. Anal. Chim. Acta 634(2), 279–285 (2009)PubMedCrossRef
192.
W.J. Kong, Y.L. Zhao, L.M. Shan, X.H. Xiao, W.Y. Guo, Spectrum-effect relationships between HPLC fingerprints and biothermo-logical activity of Zuojinwan and its similar formulaes. Acta Chim. Sinica 66(22), 2533–2538 (2008)
193.
W.J. Kong, Y.L. Zhao, L.M. Shan, X.H. Xiao, W.Y. Guo, Investigation on the spectrum-effect relationships of EtOAc extract from Radix Isatidis based on HPLC fingerprints and microcalorimetry. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 871(1), 109–114 (2008)CrossRef
194.
H.M. Lu, Y.Z. Liang, X.J. Wu, P. Qiu, Tentative fingerprint-efficacy study of Houttuynia cordata injection in quality control of traditional chinese medicine. Chem. Pharm. Bull. 54(5), 725–730 (2006)CrossRef
195.
X. Wang, A. Zhang, G. Yan, Y. Han, H. Sun, UHPLC-MS for the analytical characterization of traditional Chinese medicines. TrAC, Trends Anal. Chem. 63, 180–187 (2014)CrossRef
196.
X.F. Zhen, L. Chen, J. Tian, X. Qin, Spectrum-effect relationship of ethyl acetate fraction in ethanol extract from Xiaoyaosan (XYE-E) for antidepressant effect based on 1H-NMR. World Science and Technology/Modernization of Traditional Chinese Medicine and Materia Medica, pp. 563–568 (2015)
197.
X.D. Wu, Y. Huang X. Zhou, H.G. Chen, E.M. Hu, Z.M. Jiang, S.S. Lv, Y.F. Liang, Spectrum-effect relationship study on the anti-prostatic hyperplasia effect with HPLC spectrum of Polygonum polygonum, in The Second Doctor and Mester Forum in Guizhou, pp. 56–66 (2018)
198.
R. Rosipal H. Lodhi, Y. Yamanishi, Nonlinear partial least squares an overview, in Chemoinformatics and Advanced Machine Learning Perspectives: Complex Computational Methods and Collaborative Techniques, pp. 169–189 (2011)
199.
P. Geladi, B.R. Kowalski, Partial least-squares regression: a tutorial. Anal. Chim. Acta 185, 1–17 (1986)CrossRef
200.
X.Y. Liu, W.W. Jiang, M. Su, Y. Sun, H.M. Liu, L. Nie, H.C. Zang, Quality evaluation of traditional Chinese medicines based on fingerprinting. J. Sep. Sci. 43(1), 6–17 (2020)PubMedCrossRef
201.
Y. Peng, S.N. Li, X.X. Pei, K. Hao, The multivariate regression statistics strategy to investigate content-effect correlation of multiple components in traditional Chinese medicine based on a partial least squares method. Molecules 23(3), 545 (2018)PubMedPubMedCentralCrossRef
Metadata
Title
Advance and Challenge of Component-Effect Relationship in the Discovery of Active Components from Chinese Medicines
Authors
Wen Cao
Shaoping Li
Jing Zhao
Copyright Year
2024
Publisher
Springer Nature Singapore
Book
Quality Control of Chinese Medicines

Print ISBN: 978-981-9998-70-8

Electronic ISBN: 978-981-9998-71-5

Copyright Year: 2024

DOI
https://doi.org/10.1007/978-981-99-9871-5_5

Premium Partners

    Image Credits